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make a difference If something makes a difference, it has some impact or effect. It has some importance for something. For example, making one mistake on a test can make a difference. Maybe it changes your grade from an A to a B. If you have a really good teacher, it can make a difference in how much you learn and also in how happy you are in your class. Having one friend can make a big difference in your life. Without a friend, you might be lonely and sad. If you have even one friend, you might feel completely fine.
make no difference to not matter, or to not have any impact or cause any change.
split the difference to make a compromise with someone. [2 definitions]