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desolate without those things necessary or desirable for life; bleak; barren. [6 definitions]
despair the state of being completely without hope. [3 definitions]
desperate having no regard for danger as the result of hopelessness or great need. [4 definitions]
desperation the feeling or condition of someone or something that is desperate.
despise to hate or feel contempt for.
despite notwithstanding; regardless of. [3 definitions]
dessert a sweet or fruit served as the last course of a meal.
destination the planned end of a journey, or the place to which goods or baggage are sent. [2 definitions]
destine to specify for or send toward a particular place, end, or purpose. [2 definitions]
destiny that which has happened or must happen to someone or something because of fate or luck. [3 definitions]
destitute having no money or other means of living; impoverished. [2 definitions]
destroy to damage beyond repair; ruin. [5 definitions]
destroyer someone or something that destroys. [2 definitions]
destruction the act of destroying. [3 definitions]
destructive causing chaos or destruction. [2 definitions]
detach to separate from some whole. [2 definitions]
detail a small item; specific aspect; particular. [8 definitions]
detailed providing a good deal of information including small, but often important, pieces of information; thoroughly treated or described. [2 definitions]
detain to prevent from going on; stop or delay. [2 definitions]
detect to perceive, discover, or uncover. [2 definitions]
detective a person, often a police officer, who conducts investigations.