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bison a very large mammal with a large head, humped shoulders, and short curved horns. Bison used to roam the plains of North America in large herds, but they were hunted until they were almost extinct. North American bison are also called buffalo, but they are not related to the true buffalo of Africa and Asia. Bison have hooves and are closely related to cattle. Bison eat only plants and chew their cud. [2 definitions]
buffalo a large mammal that has long legs, hooves, and horns, and that is closely related to cattle. Different kinds of buffaloes live in Africa or Asia. The North American bison is sometimes called a buffalo, but is not a true buffalo.