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disease A disease is something wrong in your body that makes you sick or causes damage to some part of your body. Some diseases can make you sick just for a short time, but other diseases are very serious. Chicken pox and influenza are two kinds of diseases. Diseases are often caused by bacteria and viruses.
flu a short form of the word "influenza."
influenza a disease caused by a virus in humans and some animals; flu. Influenza causes fever, indigestion, coughing and muscle pain.