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around the bend (informal) crazy; insane.
crazy (informal) having a mental illness; insane. [1/4 definitions]
insane "Insane" is a word people sometimes use to describe someone whose mind has serious problems. "Insane" is a very strong word. A person who is called "insane" usually requires special care and treatment. Nowadays, it is more common to say that a person has a serious mental illness instead of saying they are "insane." [3 definitions]
mad crazy; insane. [1/6 definitions]
maniac a person who is insane. [1/3 definitions]
rational in control of one's mind; not insane or crazy. [1/3 definitions]