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desolate having no people; lonely. [2/3 definitions]
lonely When you feel lonely, you feel a little sad because you are alone. [4 definitions]
make a difference If something makes a difference, it has some impact or effect. It has some importance for something. For example, making one mistake on a test can make a difference. Maybe it changes your grade from an A to a B. If you have a really good teacher, it can make a difference in how much you learn and also in how happy you are in your class. Having one friend can make a big difference in your life. Without a friend, you might be lonely and sad. If you have even one friend, you might feel completely fine.
miss1 to feel sad or lonely without. [1/8 definitions]